mhc

Episode 24 - The Devil Went Down to... awww, C'mon Matt

Path of Devil Facial Tumor Disease. Figure 1 from  doi:10.1038/ncomms12684

Path of Devil Facial Tumor Disease. Figure 1 from doi:10.1038/ncomms12684

Audiommunity loves Tasmanian devils, so we bite the shit out of them... In this episode, we're talking about a contagious tumor that couldn't happen to a nicer species. No seriously, it really couldn't. Tasmanian devils bite each other on the face to say hello. WTF devils?

And we answer audience e-mail that's been in the inbox for months! I know, I know... we're going to record more frequently going forward - honest!

Links

Paper: Rapid evolutionary response to a transmissible cancer in Tasmanian devils

Gross pictures of devil tumor facial disease

Episode 001 – Everyone else’s kidneys

Download episode. In this episode, we're talking transplantation: Why is it so damned hard to transfer tumors between mice? Why do we have to go to extraordinary lengths to transplant kidneys between humans?

To serve as our guide, we go through two papers – A historical paper on the emergence of MHC in the immunological field, and a recent paper describing some cool tricks that immunologists are using to more effectively transplant organs between patients – without immune suppression. Along the way, we discuss tumor transplantation in inbred mice, Tasmanian devil face cancer, transplantrejection, the legacy of the Cavendish family (think banana), and just a touch of Tcellbiology. Happy listening!

------------

Links:

George D Snell and George F Higgens, "Alleles at the histocompatability-2 locus in the mouse as determined by tumor transplantation."Genetics (1951)

Tatsuo Kawai et.al. "HLA-Mismatched renal transplantation without maintenance immunosuppression." New England Journal of Medicine (2008)