Figure 2 B from https://doi.org/10.1073/pnas.1716937115
In this episode, Chadene, Kate and Kevin discuss Kate's recently published paper about how STING, once thought to be involved only in defense against DNA viruses, actually slows RNA virus replication as well. Also, Chadene throws herself under the bus, and Kevin manages to only talk for about 20% of the time.
No, your eyes aren't deceiving you, and yes, we know how to count... Episode 29 is still in limbo as Camilla valiantly attempts to re-record just her portion.
In this episode, Kevin and Camilla discuss Salmonella virulence, and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job.
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EDIT: Sorry if this showed up in your feed late - there was a mistake in formatting :-(
In this episode, Kevin talks with Pamela Ronald, professor of plant pathology at the University of California, Davis. Almost 20 years ago, Ronald discovered Xa21, a plant pattern recognition receptor that guards against bacterial infection. This receptor shares many features with Toll-like receptors, and the role of Xa21 was shown a year before TLRs were implicated in immunity.
We also talk about recent work from Ronald's lab, in which bananas, a staple crop for millions of people in Africa, are genetically engineered to express Xa21 in order to protect them from a devastating bacterial infection.
Neutrophils are specialized for killing things. Often described as the kamikaze pilots of the immune system, they typically swarm into sights of inflammation to kill everything that looks out of place. Neutrophils don't typically live very long, and then they die, they can do so by committing suicide in a way that causes further destruction.
Lots of cells commit suicide (we talk about that too), but neutrophils have a special suicide called "NETosis," where they release their genomic DNA to envelop and kill bacteria.
Matt and I have been a bit delinquent with the graphics, but we're working on more, as well as some animations (both of us are trying to learn to make animations in HTML5 at the moment).