Episode 31 - Two Bucket Disease

Graphical abstract from the paper. Guys, Matt and I don't charge that much to help with figure design...

Graphical abstract from the paper. Guys, Matt and I don't charge that much to help with figure design...

In this episode, we're talking about Salmonella, and the peculiar way in which it tries to keep you eating to keep you alive. Who knew pathogens could be so kind?

Also, Chadene struggles to introduce the podcast, and Kate decides to Kevin 4 years later that we're misspelling the name of the podcast. Too late now!


The Paper: Pathogen-mediated inhibition of anorexia promotes host survival and transmission
Kate's Shandy (Sorry, I refuse to put a link to Rolling Rock)
Resorb - (eg Scandinavian magic)

Episode 30 - No Drop Shadows on Error Bars

Neutrophil grabbing Staph.  From Wikipedia

Neutrophil grabbing Staph. From Wikipedia

No, your eyes aren't deceiving you, and yes, we know how to count... Episode 29 is still in limbo as Camilla valiantly attempts to re-record just her portion. 

In this episode, Kevin and Camilla discuss Salmonella virulence, and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job.

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EDIT: Sorry if this showed up in your feed late - there was a mistake in formatting :-(


The Paper: Strains of bacterial species induce a greatly varied acute adaptive immune response: the contribution of the accessory genome
Short Path Distillery
Organ Preservation Alliance (where Kate works now)

Episode 5 - When the Carnies Roll In

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In Episode 5, we're talking about neutrophils, and the special way they die.

Neutrophils are specialized for killing things. Often described as the kamikaze pilots of the immune system, they typically swarm into sights of inflammation to kill everything that looks out of place. Neutrophils don't typically live very long, and then they die, they can do so by committing suicide in a way that causes further destruction.

Lots of cells commit suicide (we talk about that too), but neutrophils have a special suicide called "NETosis," where they release their genomic DNA to envelop and kill bacteria.

Matt and I have been a bit delinquent with the graphics, but we're working on more, as well as some animations (both of us are trying to learn to make animations in HTML5 at the moment).

Hope you enjoy the show, and don't forget to rate us on itunes or like us on facebook.


The paper: Brinkmann et. al. "Neutrophil Extracellular Traps Kill Bacteria" Nature. (2004)

Videos of neutrophil swarming (the second one is my favorite)

Ticking clock sound effect by soundcloud user kazukied2