Episode 19 - J Lo Poop Pills

By SuSanA Secretariat - https://www.flickr.com/photos/gtzecosan/16424898321/, CC BY 2.0

By SuSanA Secretariat - https://www.flickr.com/photos/gtzecosan/16424898321/, CC BY 2.0

In this episode, how parasitic worms alter in immunomodulatory effects of the gut microbiome. Also, Kate expresses her distaste for large datasets and animal experiments, and Matt proposes a weight loss company that will only market to identical twins.

Links

The paper: The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Original paper on gut microbes and short chain fatty acids

The company that Kevin couldn't remember: Seres Therapeutics

Episode 18 - More cow... sirens?

Chemical structure of cGAMP - the "A" is on the bottom left, the "G" on the upper right and the "cyclic" part is that linkage in the middle between the sugars and the phosphate groups.

Chemical structure of cGAMP - the "A" is on the bottom left, the "G" on the upper right and the "cyclic" part is that linkage in the middle between the sugars and the phosphate groups.

In this episode, we talk about the innate immune system's Trojan cow strategy - using a cyclic dinucleotide as a signaling molecule means that viruses can package the seeds of their own destruction. 

Meanwhile, Matt and Kate throw Kevin under the bus with regards to alcohol consumption, and Matt expounds on the security threat posed by infectious cattle. 


Episode 17 - When your immune system is all up in it

In this episode we talk about lymphatics in the brain and why that's both obvious and not obvious. Meanwhile, Kate drinks disgusting smoothies and Kevin triggers Matt with a trigger warning.

Gross Smoothie Recipe

2 cups plain kefir
2 Tbsp almond butter
1 cup chopped baby kale
1 banana (Cavendish!)
1/3 cup oatmeal
1/2 scoop protein powder
1 dash cayenne pepper

Blend all ingredients, hold nose and consume. 
 

Links:

The Paper: Structural and functional features of central nervous system lymphatic vessels
The Structure of Scientific Revolutions
Lymphatic System
 

Episode 16 - Jimmy Carter's Brain on Drugs

Taking the breaks off of the immune system can get it to attack cancer cells

Taking the breaks off of the immune system can get it to attack cancer cells

In this episode, Matt and Kevin discuss checkpoint blockade cancer immunotherapy (wow, that's a mouthful). When cancer stamps down the breaks of the immune system, cutting the break line can allow T-cells to do their job. 

Meanwhile, Kate's teeth are falling out of her head, and Matt can't even remember what scotch he's drinking. 

This episode was recorded Friday, Jan 8th... we're getting better folks. 

Links:

Episode 15 - The other DRACO

Nope... not that Draco. Source

Nope... not that Draco. Source

This week, we're discussing DRACOs - not the Harry Potter character, a "new" class of antiviral therapeutics that links up the double-stranded RNA-binding part of one protein to the cell-death (apoPtosis)-activating part of a different protein.

The paper we're discussing was published over 4 years ago, but the idea hasn't seemed to take off - we'll discuss the promise of the idea, but also our concerns and skepticism, the later of which is particularly important since the original author is now embarking on a crowd funding campaign to get more money to study it. 


Rachel Rynick upcoming performance in Dedham, MA